Rejuran, Sculptra, and Radiesse can’t be compared simply by asking “which one has the best results.” Rejuran’s key ingredient is PN, and its suitability is typically assessed based on fine lines and skin texture needs; Sculptra uses PLLA, focusing on gradually stimulating collagen production to improve volume and provide structural support; Radiesse contains CaHA, offering both immediate support and subsequent biological stimulation effects. When making a choice, it’s important first to determine whether you want to improve skin quality, fill in depressions, or enhance facial contours, then consider factors such as the treatment area, tissue thickness, previous injections, and associated risks.
All three can be categorized by clinics or online communities under headings like “collagen regeneration” or “collagen proliferation,” but the materials used, injection depths, rate of results, and appropriate treatment issues vary. The comparison below is intended to help you prepare for a in-person consultation—it should not replace a doctor’s decision on which product and treatment method is best suited to your individual situation.
Let’s start with the conclusion: The differences between Rejuran, Sculptra, and Radiesse
| Treatment course | Key Ingredients | Common Goals of In-Person Consultations | Changing Characteristics | Pay special attention to this during planning. |
|---|---|---|---|---|
| Rejuran – The Power of Rejuran | PN, polynucleotide | Fine lines, skin quality, and localized skin conditions | It should focus on skin type goals and not be used directly as a substitute for contour filling. | Product version, injection site, injection reactions, and medical history related to fish-derived ingredients |
| Sculptra / SWOMAN Injection | PLLA, poly(l-lactic acid) particles | Gradual volume, support, and collagen stimulation | Changes usually emerge gradually, and planning often requires observation over phases. | Dilution, layering, distribution, number of treatment sessions, and risks such as papules or nodules |
| Radiesse / Juvederm | CaHA, Hydroxyapatite Calcium Microsphere Gel | Contour, support, volume; different dilution methods lead to various discussion topics | Gel carriers provide more immediate support, along with bio-stimulatory properties over time. | Site, depth, whether diluted, irreversibility, and vascular-related risks |
This form cannot be used to specify the dosage or treatment area on your own. The approved indications for the same product may vary across different countries or regions; doctors also need to make decisions based on the product’s prescription, local regulations, and individual anatomical conditions.
Rejuran: A choice that better fits based on skin type
According to the official information provided by Rejuran, its key ingredient is PN (polynucleotide). The approved use as listed by the manufacturer is to temporarily reduce facial wrinkles. In South Korea, it is often categorized under skin boosters or skin regeneration products, which means that consultations usually focus on fine lines, skin texture, and the condition of specific areas of the skin.
What concerns can you discuss with a doctor regarding Rejuran?
- Worried about fine lines, skin texture, or dryness and roughness.
- Looking to assess the skin condition around the eyes or across the entire face, without aiming for significant contour shaping.
- I’m okay with common side effects after injections such as pinprick marks, temporary swelling, redness, or bruising.
- We recommend conducting assessments in stages based on your skin condition and responses, rather than treating a single treatment as a final solution.
Rejuran is available in various versions and packaging styles. Similar names do not necessarily mean identical uses, concentrations, volumes, or application areas. Be sure to confirm the exact product name when making an appointment, and double-check the packaging, volume, expiration date, and whether it has been opened in front of you before use.
What questions is Rejuran not suitable for answering?
If the main concerns are noticeable hollows, insufficient contour support, or a need for predictable volume changes, simply asking “How many centum core Rejuran should be injected?” may not address the core issue. Doctors still need to determine whether the hollows stem from bone structure, fat changes, ligaments, skin conditions, or previous treatments. Different underlying causes may require alternative approaches, or injections might not be suitable in such cases for now.
Sculptra: A PLLA bio-stimulant that gradually builds volume and support
Sculptra is an injectable filler that contains PLLA (poly-L-lactic acid) particles. The FDA and the manufacturer describe it as a product that stimulates the body’s natural collagen production; clinical improvements are typically gradual, rather than considering the amount of moisture or swelling present on the day of injection as the final outcome.
What questions can you ask a doctor about Sculptra?
- There is significant volume loss or reduced support in the face, with a desire for changes to occur gradually.
- Concerned about the shape of the face, cheeks, or overall structure, but not aiming for an immediate defined look.
- Multiple treatment sessions, waiting periods, and follow-ups are acceptable—there’s no need to complete all adjustments in one go.
- Willing to provide a complete record of past fillers, collagen stimulants, thread lifting, surgeries, or nodules.
The results of Sculptra are influenced by factors such as concentration, injection depth, distribution, treatment area, and the skill of the practitioner. The FDA label also provides important warnings about the potential for papules and nodules, as well as indicating that it should not be used by those allergic to its components or who are prone to developing keloid scars or hypertrophic scarring. Actual contraindications and individual risks must be assessed by a physician based on local guidelines.
Why shouldn’t Sculptra be judged solely by “how much per bottle”?
The price of one bottle doesn’t reflect the total cost of a complete treatment, nor can it be used to determine the appropriate number of bottles needed. When making comparisons, make sure to ask about the full product name, specifications per bottle, the area to be treated, the dilution method, how many sessions are required, who will perform the treatment, what follow-up arrangements are in place, and how to handle any abnormal lumps or delayed reactions that may occur.
Radiesse: A CaHA filler that offers both structural support and bio-stimulatory effects
The key component of Radiesse are CaHA (calcium hydroxylapatite) microspheres, suspended in a gel matrix. According to the manufacturer, it provides immediate volume support and later contributes to the formation of collagen and elastin; however, its actual effects vary depending on the injection depth, location, and whether it is diluted or not.
What concerns can you discuss with a doctor regarding Radiesse?
- The main goals include contouring or structural support, and patients hope doctors can assess the need for immediate support.
- I’d like to know about the planning differences of CaHA for specific areas under different dilution methods.
- One can accept that it can’t be dissolved with hyaluronidase like Filler, and is willing to thoroughly discuss the risks and alternative options.
- We determine suitability based on anatomical layers, skin thickness, and previous injection history.
The application method for Radiesse varies depending on the area being treated. FDA-approved uses include specific facial wrinkles, jawline shaping, and other particular applications, but approval ranges differ by region. Areas around the eyes, nose, lips, or other high-risk zones should never be treated based solely on testimonials found online.
What’s the biggest difference in decision-making between Radiesse and Filler?
A key difference lies in reversibility. In certain cases, Filler can be treated with hyaluronidase under a doctor’s evaluation; CaHA doesn’t have such a specific method for dissolution. Therefore, it’s particularly important to verify the treatment area, depth, dosage, authenticity of the product, and the practitioner’s experience before proceeding with the procedure.
Want to improve skin texture, sagging, or contours? How should you choose?
Mainly fine lines and skin texture
You can first discuss whether a PN treatment regimen like Rejuran meets your goals, while ruling out any existing skin issues such as inflammation, infection, uncontrolled sensitivity, or other conditions that need to be treated first. If you’re hoping for significant lifting or filling of wrinkles, make sure to ask the doctor about what such skincare treatments can achieve in your specific case.
It’s mainly due to widespread volume loss.
You can ask your doctor to compare the gradual approach of Sculptra with that of other bio-stimulants and Fillers, or the option of waiting before undergoing any treatment. The decision isn’t just about the type of material used, but also which areas need enhancement, which areas should be left unchanged, and whether the rate of improvement matches your expectations.
It’s mainly about contouring and structural support.
Radiesse or other augmentation options can be discussed, but it’s first necessary to assess tissue thickness, the target area, and any anatomical risks. If there is also skin laxity, fat accumulation, or noticeable hollows, a single filler may not be sufficient to address all of these issues.
All three needs exist simultaneously
Start by setting priorities — there’s no need to complete all three procedures on the same day. You can break down your goals into three categories: skin quality, volume, and contour. Ask your doctor to explain the sequence, intervals, potential interactions between the procedures, and when to stop each step. Planning in stages also makes it easier to observe how things progress and determine whether further steps are still necessary.
Can Rejuran, Sculptra, and Radiesse be used together?
Theoretical “compatibility” doesn’t mean everyone needs to combine treatments. Whether they can be done on the same day or in separate sessions depends on factors such as the treatment area, number of layers, products used, health status, previous treatments, and the doctor’s judgment. If a clinic offers fixed packages without clearly explaining the rationale behind each treatment and its sequence, it’s better to postpone making a decision for now.
Make sure to ask clearly before starting a combined treatment plan:
- Which problem does each product address?
- Do the application areas and layers overlap?
- Why do it on the same day? What’s the difference between doing it in stages?
- Which reaction might affect the observation of the other?
- When asymmetry, lumps, persistent redness, or other abnormalities occur, how can you determine their source?
What are the common risks of collagen regeneration injections?
Common reactions after injection may include pain, redness, swelling, bruising, tenderness, itching, or temporary unevenness; different materials can also cause papules, nodules, inflammatory responses, or other specific risks. Any facial injection also requires discussion of rare but serious vascular-related complications, including tissue ischemia, vision impairment, or stroke risk.
You should proactively inform them before the procedure:
- History of allergies, including fish-related allergies or concerns about product ingredients.
- History of autoimmune diseases, immunosuppression, coagulation disorders, or telangiectasia/hypertrophic scarring.
- Pregnancy, breastfeeding, infections, inflamed skin, or recent Dental and other medical procedures.
- Prescription drugs, anticoagulants, pain relievers, and health supplements; never stop taking medications on your own.
- Past fillers, bio-stimulants, thread lifting, surgeries, dissolution, and adverse reactions.
If you experience severe pain after the injection, pale or mottled skin, changes in vision, eye pain, difficulty speaking, weakness in your limbs, or other symptoms that worsen rapidly, seek emergency medical help immediately—don’t wait for a response from customer service online.
How can we meaningfully compare the prices of collagen regeneration treatments in South Korea?
Don’t just compare the advertising figures for “1 centum core” or “one bottle.” Rejuran is typically measured by syringe volume, Sculptra is usually presented in terms of the number of bottles and treatment plans, while Radiesse requires attention to the specifications of each vial, whether it’s diluted or not, and its intended use. With such different units, it’s impossible to simply rank them based on price alone.
You can request the following information before making an appointment:
- Full product name, version, specifications, and quantity.
- Was the original packaging checked and opened on site?
- Recommendations on treatment areas, number of sessions, practitioner, and whether multiple treatments are needed.
- Are anesthesia, consumables, postoperative medications, and follow-up services charged separately?
- Is the quote in Korean won or another currency, and does it include VAT?
- If the plan changes after a face consultation, will the total cost be confirmed again before the procedure?
Read more:How can you determine the prices for anti-aging cosmetic procedures in South Korea?。
Head to Cheongdam for collagen regeneration treatment—bring this list with you during your in-person consultation.
- State the main goal in one sentence: skin texture, sagging, or contours—choose one first.
- List the features you’d like to keep, as well as any changes that are unacceptable.
- Organize records of injections, thread lifting, energy treatments, and surgeries from the past two years.
- Ask the doctor to explain the materials, number of layers, treatment area, and reasons for the choice.
- Ask about alternative options, including Filler, energy therapies, phased treatment, or delaying the procedure.
- Find out about common side effects, red flags, and contact information after returning to Taiwan.
- Before proceeding with the procedure, check the original packaging, specifications, quantity, total price in Korean won, and VAT.
If the indentation is concentrated around the Nasolabial Fold Correction or the mid-face, read first.Is Nasolabial Fold Correction really necessary?; If you’re still comparing clinics, you can refer to this.How to choose an anti-aging medical beauty clinic in Seoul?。
Get a consultation for collagen regeneration therapy at NEWYOUNG Clinic
NEWYOUNG Clinic / NEWYOUNG Dermatology (뉴영의원; also known in traditional Chinese characters as 清潭紐漾皮膚科) is located in Cheongdam, Seoul. It is a doctor-led clinic specializing in non-surgical cosmetic treatments. Dr. Oh Seo Joon personally conducts one-on-one consultations, offering services such as collagen regeneration, non-surgical anti-aging treatments, contour tightening, skin repair, natural rejuvenation, and safe injection assessments.
For Taiwanese travelers who are comparing Rejuran, Sculptra, and Radiesse, a in-person consultation allows them to break down their needs into skin type, volume, and contouring goals, before deciding on the appropriate materials, treatment areas, number of layers, and sequence of procedures. Based on current information, the clinic offers full accompaniment by a Chinese-speaking translator throughout the process, opens the injections right in front of the client, and avoids any forced sales tactics. Both local South Korea customers and foreign visitors pay the same price, which is listed in Korean won and does not include VAT. The final treatment plan and cost will be confirmed by the clinic director after the consultation and prior to the procedure.
The address is 78-9 Cheongdam-dong, Gangnam-gu, Seoul (06014), approximately 118 meters from Exit 3 of Apgujeong Rodeo Station. Official website:NEWYOUNG Clinic；LINE：@096fpaajIf you’d like to learn more about the clinic model first, you can read:What kind of clinic is NEWYOUNG Clinic?。
Conclusion: Choose the problem first, then the material.
If fine lines and skin quality are your primary concerns, you might want to discuss Rejuran with a doctor first. For more comprehensive issues related to volume and firmness that you’d like to address over time, consider Sculptra. If you’re looking for quicker improvement in contour support, Radiesse could be a good option. These are just starting points for a consultation—they cannot replace personalized assessments based on the specific area, depth of treatment, medical history, and previous injections.
A truly useful recommendation for collagen regeneration treatments in South Korea should be able to answer four key questions: which layer needs to be treated, why this specific material was chosen, what the risks and alternative options are, and how to monitor the results after returning to Taiwan. If the answers aren’t clear, it’s better to wait before proceeding with the treatment.
Medical Disclaimer:This article is intended for general educational purposes and to help you prepare for in-person consultations in South Korea. It cannot replace a doctor’s diagnosis, in-person evaluation, or personalized medical advice. Product indications and approved uses vary by country or region; treatment suitability, dosage, application areas, outcomes, risks, and recovery times all differ from person to person.
5. FAQ
What’s the biggest difference among Rejuran, Sculptra, and Radiesse?
At the heart of Rejuran is PN, which is typically assessed based on fine lines and skin texture needs. Sculptra uses PLLA and focuses on gradually stimulating collagen production to enhance volume and support. Radiesse, made from CaHA, offers more immediate support along with subsequent bio-stimulatory effects. Since these three products have different materials and treatment mechanisms, it’s not appropriate to compare them solely based on brand or price.
Looking to improve Pores and fine lines? Is Rejuran the right choice?
Rejuran is often used to assess skin texture and fine lines, but whether it’s suitable depends on whether the skin has inflammation, infection, uncontrolled sensitivity, or other issues. The appearance of Pores can also be related to sebum, acne scars, elasticity, and photoaging, so it’s important to identify the underlying causes first.
Can you see results immediately after getting Sculptra?
Sculptra’s collagen stimulation and structural changes typically occur gradually, and any moisture retention or swelling on the day of injection should not be considered the final result. The number of treatment sessions, intervals between them, and observation period should be determined by a physician based on the product instructions and the individual’s specific condition.
Can Radiesse be dissolved just like Filler?
The key component of Radiesse is CaHA, and it doesn’t have the same mechanism as Filler, which can be treated with hyaluronidase. Before the procedure, it’s essential to confirm the treatment area, depth, dosage, alternative options, and the practitioner’s experience.
Can the three collagen regeneration treatments be done on the same day?
Whether it can be done on the same day depends on the treatment area, depth of penetration, product used, overall health status, and previous treatments. Just because certain options can be combined doesn’t mean they have to be; the doctor should clearly explain the purpose of each option, the sequence in which they should be applied, and how to recognize post-treatment reactions.
What documents do you need to bring when going to South Korea for collagen augmentation?
Bring along records of injections, thread lifting, surgeries, and energy therapy treatments from the past two years, as well as information on allergies, illnesses, medications, and any adverse reactions. If you know the product name, dosage, treatment area, and date, it’s best to include that as well; don’t guess if you’re unsure.
How can I compare prices for collagen regeneration treatments in South Korea?
First, confirm the full product name, version, volume or number of vials, treatment area, practitioner, number of sessions, additional fees, and VAT. Rejuran, Sculptra, and Radiesse have different pricing units and planning methods, so relying solely on figures from an advertisement can lead to misleading information.
How to Choose a Collagen Regeneration Clinic in Seoul?
Observe whether the doctor can identify issues related to skin type, volume, and contours, and ask about the materials used, the number of layers applied, alternative options, significant risks, and follow-up care after returning to Taiwan. The products should be available for inspection before the procedure, and the total cost should also be confirmed prior to treatment.